Buses will be used to transport commuters during railway works.
The replacement bus service will transport people travelling from Wellingborough, Kettering and Corby when track switches and crossings known as ‘points’ are upgraded from Friday, February 24, until Monday February 27.
There will be no direct trains travelling to or from London St Pancras International and the north.
People wanting to travel South will need to catch a bus to Bedford before catching the train from there.
Those travelling from the capital to Wellingborough, Kettering and Corby will have to catch a train to Bedford before boarding a bus to their final destination.
Gary Walsh, the area director for Network Rail in the East Midlands, said: “The work we are doing in Kettering is a vital stage in our project to upgrade the Midland Main Line, as part of our Railway Upgrade Plan.
“When the Kettering to Corby upgrade is completed in 2018, trains will need to be able to move from the current track to the newly installed one.
“This work will allow them to do so, which will enable more trains to run and will benefit passengers.
“I’d like to remind passengers who plan on travelling to London from north of Kettering to check before they travel and apologise to them for any inconvenience caused.”